Bad Romance, by Lady Gaga.
Technically released in 2009 (October 20, 2009), Bad Romance has carried over into 2010 and was a heavy influence of many fun nights and closing numbers of Gaga concerts I witnessed. In fact I specifically requested this song to ring in 2010 while at a club in LA on NYE. I cannot wait to see what Gaga has in store for me in 2011!